Basic information about memantine and its treatment of Alzheimer's disease and other clinical applications

Memantine is a noncompetitive moderate-affinity strong voltage-dependent N-methyl-D-aspartate receptor antagonist. It has been used to treat Alzheimer's disease (AD) since 1989. In 2018, it became the second most commonly drug for treatment of dementia in world. AD nonreversible, and memantine can only relieve symptoms but not cure it. Over past half-century, memantine's research clinical application have extensively developed. this review, basic composition memantine, mechanism limitations AD, combination therapy, comparison with other drugs studies diseases are reviewed provide valuable reference further AD.